Physiology
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    Guide PCI with coronary physiology

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    Final CEE consent

    Are you using physiology?

    iFR is now recommended by the European Society of Cardiology (ESC) guidelines 8

    Recommendations

    Class

    Level

    iFR/FFR to identify hemodynamically relevant coronary lesion(s) in stable patients when evidence of ischemia is not available

    I

    A

    FFR-guided PCI in patients with multivessel disease.

    IIa

    B

    DEFINE PCI:

    Unseen focal lesions cause residual ischemia

    The DEFINE PCI study used iFR pullback to understand the rate and causes of residual ischemia in 500 patients undergoing contemporary PCI. Early results find that residual ischemia is common, and causes are treatable.13

    1 in 4
    Unseen focal

    Angiographically focal stenosis defined as ≤ 15 mm.13

    TCTMD roundtable video

    DEFINE PCI – experts discuss the key finding

    2nd roundtable video

    Allen Jeremias  discusses: DEFINE PCI

    The power of choice

     

    Philips provides you with the opportunity to use iFR which is the only clinically validated resting index (recommended by AHA and SCAI) along with FFR. In 2017 Davies et al. and Götberg et al. validated the non-inferiority of iFR compared to FFR .

    coronary pressure

    FFR = Distal Coronary Pressure (Pd)

    Promixal Coronary Pressure (Pa)

    (During maximal hyperemia)

    Distal Coronary Pressure

    iFR = Distal Coronary Pressure (Pd)

    Promixal Coronary Pressure (Pa)

    (During wave-free period)

    FFR image

    FFR

    A physiology index to determine the functional significance of coronary stenosis. FFR is the ratio of the distal pressure compared to the proximal pressure during maximal blood flow (hyperemia), which can be induced by injecting products such as adenosine or papaverine.

    iFR image

    iFR

    iFR provides a hyperemia-free measurement in as few as five heartbeats. Pressure and flow correlate when resistance is consistant P = Q * R. iFR is measured during the wave-free period when resistance is naturally constant.

    Diagram treat and defer

    Proven outcomes

     

    • Validated in more than 4,500 patients9,10
    • Consistent outcomes as with FFR
    • 0.89 cut-point backed by data9,10,12

    europcr 2018 web graphics char

    Superior value

     

    • 10% Cost saving per patient11
    • 10% reduction in procedure time
    • 90% reduction in patient discomfort9
  • 10% Cost saving per patient
  • 10% reduction in procedure time
  • 90% reduction in patient discomfort1
  • 10% Cost saving per patient
  • 10% reduction in procedure time
  • 90% reduction in patient discomfort1
  • europcr 2018 web graphics cluster

    Be sure with iFR guidance

    In-depth information for lesion specific ischemia

       



    The Cardiovascular Center of Catania prefers to use iFR over FFR, for its savings on time, contrast and stents. They are frequent users of iFR Scout and iFR Co-Registration.

    ifr thumb
    ifr scout

    iFR Scout

     

    • Provides beat-by-beat pressure measurements across the entire vessel, artery by artery
    • Establishes the physiological significance of each vessel and/or individual lesion (focal or diffuse)
    • Provides a clear view of the functional gain from treating
    • Facilitates multiple assessments before, during and after the procedure (without the need for hyperemia)

    ifr co reg

    iFR Co-Registration

     

    • Visualization of pressure gradients to facilitate stent planning on SyncVision system
    • Provides mapping of physiology information into the anatomy image
    • Allows length measurement to be made on to the angiogram
    • Seamless integration into your PCI
    • Provides iFR estimated value post-stenting allowing for virtual stenting functionality

    Watch a case study on the LAD with diffuse disease


    Davide Capodanno MD and Alessio La Manna MD, practicing interventional cardiologists at University of Catania explain the advantages of iFR Co-Registration to optimally treat diffuse disease in the LAD.

    ifr thumb

    LAD deferral is safer with iFR

     

     

    Sen etal . (2019, JACC), Deferral of LAD revascularization based on iFR appears to be safe and is associated with 53% lower MACE rates when compared against FFR.

    lad deferral
    Ephysiology/graphthumb image

    “In this study, we have clearly demonstrated that it is safe to defer on the basis of iFR. If I see a patient with an LAD lesion, I'm only reassured for medical therapy if the iFR is negative.”

    Dr. Sayan Sen, Consultant Cardiologist, Hammersmith Hospital & Imperial College London, discusses details of the LAD sub-study of DEFINE-FLAIR

    DEFINE-FLAIR LAD Sub-Study Aims

    Study aims

    DEFINE-FLAIR LAD Sub-Study Aims

    iFR and FFR results

    DEFINE-FLAIR LAD Sub-Study Aims

    Value of iFR and Co-registration

    •  

      SyncVision  

      The SyncVision precision guidance system is suitable with IntraSight and Core Integrated interventional platforms and streamlines lesion assessment, simplifies vessel sizing and enables precise therapy delivery all while integrating seamlessly in daily workflows in interventional suites of choice.

    •  

      Verrata  

      Experience the freedom of untethered steering from tip to clip. Many factors impact wire performance including tip design, wire support, and torque response. Fundamental to guide wire handling is the ability to maneuver the wire untethered. The Verrata pressure guide wire quickly disconnects and reliably reconnects, freeing physicians to steer like a frontline wire.*

      989604186581
    •  

      Verrata Plus  

      For over 20 years Philips has led the way in physiology, putting patients first through continuous innovation. Now introducing our 10ᵗʰ generation physiology wire: Verrata Plus.

      989604186571
    •  

      Core  

      The Core precision guided therapy systems offer the choice of imaging and physiology on a single integrated platform.¹ Core helps provide clarity in your approach, confidence in your decisions, and convenience in your diagnostic and interventional workflows.

    •  

      Core Mobile  

      Core Mobile is designed to power the future of precision guided therapy and offers the choice of imaging and physiology on a single mobile platform.¹ Core Mobile also provides clarity in your approach and confidence in your results by offering additional information during the diagnostic phase, assisting in intervention decisions.

      IGTDCOREM

    References

    1. Curzen N, et al. Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain?: the RIPCORD study. Circ Cardiovasc Interv. 2014. Apr;7(2):248-55. doi :10.1161/ CIRCINTERVENTIONS.113.000978.
    2. Zir LM et al. Interobserver variability in coronary angiography. Circulation. 1976;53:627–632.
    3. Leape L et al. Effect of variability in the interpretation of coronary angiograms on the appropriateness of use of coronary revascularisation procedures. Am Heart J. 2000;139:106–113.
    4. Cameron A et al. Left main coronary artery stenosis: angiographic determination. Circulation. 1983;68:484–489.
    5. Van Belle E, et al. Outcome impact of coronary revascularization strategy reclassification with fractional flow reserve at time of diagnostic angiography: insights from a large French multicenter fractional flow reserve registry. Circulation. 2014;129(2):173–185. doi :10.1161/ CIRCULATIONAHA.113.006646.
    6. Baptista S.B, et al. the POST-IT ( POrtuguese Study on The Evaluation of FFR- guided Treatment of coronary disease) prospective multicentre registry. Abstract presented at late-breaking clinical trial session at EuroPCR 2014.
    7. De Bruyne B, Sarma J, Heart. 2008;94(7):949-59.
    8. Neumann, F.-J. et al. 2018 ESC/EACTS Guidelines on myocardial revascularization. European heart journal (2018).
    9. Davies JE, et al., DEFINE-FLAIR: A Multi- Centre , Prospective, International, Randomized, Blinded Comparison of Clinical Outcomes and Cost Efficiencies of iFR and FFR Decision-Making for Physiological Guided Coronary Revascularization. New England Journal of Medicine, epub March 18, 2017
    10. Gotberg M, et al., Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve Guided Intervention (IFR-SWEDEHEART): A Multicenter, Prospective, Registry-Based Randomized Clinical Trial. New England Journal of Medicine, epub March 18, 2017
    11. Patel M. “Cost-effectiveness of instantaneous wave-Free Ratio (iFR) compared with Fractional Flow Reserve (FFR) to guide coronary revascularization decision-making.” Late-breaking Clinical Trial presentation at ACC on March 10, 2018.  
    12. An iFR cut-point of 0.89 matches best with an FFR ischemic cut-point of 0.80 with a specificity of 87.8% and sensitivity of 73.0%. (From ADVISE II, and iFR Operator’s Manual 505-0101.23

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